The Oral Microbiome of Denture Wearers Is Influenced by Levels of Natural Dentition
Identifieur interne : 000C55 ( Main/Exploration ); précédent : 000C54; suivant : 000C56The Oral Microbiome of Denture Wearers Is Influenced by Levels of Natural Dentition
Auteurs : Lindsay E. O Onnell [Royaume-Uni] ; Douglas Robertson [Royaume-Uni] ; Christopher J. Nile [Royaume-Uni] ; Laura J. Cross [Royaume-Uni] ; Marcello Riggio [Royaume-Uni] ; Andrea Sherriff [Royaume-Uni] ; David Bradshaw [Royaume-Uni] ; Margaret Lambert [Royaume-Uni] ; Jennifer Malcolm [Royaume-Uni] ; Mark J. Buijs [Pays-Bas] ; Egija Zaura [Pays-Bas] ; Wim Crielaard [Pays-Bas] ; Bernd W. Brandt [Pays-Bas] ; Gordon Ramage [Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The composition of dental plaque has been well defined, whereas currently there is limited understanding of the composition of denture plaque and how it directly influences denture related stomatitis (DS). The aims of this study were to compare the microbiomes of denture wearers, and to understand the implications of these towards inter-kingdom and host-pathogen interactions within the oral cavity.
Swab samples were obtained from 123 participants wearing either a complete or partial denture; the bacterial composition of each sample was determined using bar-coded illumina MiSeq sequencing of the bacterial hypervariable V4 region of 16S rDNA. Sequencing data processing was undertaken using QIIME, clustered in Operational Taxonomic Units (OTUs) and assigned to taxonomy. The dentures were sonicated to remove the microbial flora residing on the prosthesis, sonicate was then cultured using diagnostic colorex
We have shown that dental and denture plaques are significantly distinct both in composition and diversity and that the oral microbiome composition of a denture wearer is variable and is influenced by the location within the mouth. Dentures and mucosa were predominantly made up of Bacilli and Actinobacteria. Moreover, the presence of natural teeth has a significant impact on the overall microbial composition, when compared to the fully edentulous. Furthermore, increasing levels of
This is the first study to provide a detailed understanding of the oral microbiome of denture wearers and has provided evidence that DS development is more complex than simply a candidal infection. Both fungal and bacterial kingdoms clearly play a role in defining the progression of DS, though we were unable to show a defined role for AMPs.
Url:
DOI: 10.1371/journal.pone.0137717
PubMed: 26368937
PubMed Central: 4569385
Affiliations:
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O Onnell</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Robertson, Douglas" sort="Robertson, Douglas" uniqKey="Robertson D" first="Douglas" last="Robertson">Douglas Robertson</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Nile, Christopher J" sort="Nile, Christopher J" uniqKey="Nile C" first="Christopher J." last="Nile">Christopher J. 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Buijs</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Brandt, Bernd W" sort="Brandt, Bernd W" uniqKey="Brandt B" first="Bernd W." last="Brandt">Bernd W. 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O Onnell</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Robertson, Douglas" sort="Robertson, Douglas" uniqKey="Robertson D" first="Douglas" last="Robertson">Douglas Robertson</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Nile, Christopher J" sort="Nile, Christopher J" uniqKey="Nile C" first="Christopher J." last="Nile">Christopher J. Nile</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Cross, Laura J" sort="Cross, Laura J" uniqKey="Cross L" first="Laura J." last="Cross">Laura J. Cross</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Riggio, Marcello" sort="Riggio, Marcello" uniqKey="Riggio M" first="Marcello" last="Riggio">Marcello Riggio</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sherriff, Andrea" sort="Sherriff, Andrea" uniqKey="Sherriff A" first="Andrea" last="Sherriff">Andrea Sherriff</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bradshaw, David" sort="Bradshaw, David" uniqKey="Bradshaw D" first="David" last="Bradshaw">David Bradshaw</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Margaret" sort="Lambert, Margaret" uniqKey="Lambert M" first="Margaret" last="Lambert">Margaret Lambert</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Malcolm, Jennifer" sort="Malcolm, Jennifer" uniqKey="Malcolm J" first="Jennifer" last="Malcolm">Jennifer Malcolm</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Buijs, Mark J" sort="Buijs, Mark J" uniqKey="Buijs M" first="Mark J." last="Buijs">Mark J. Buijs</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Brandt, Bernd W" sort="Brandt, Bernd W" uniqKey="Brandt B" first="Bernd W." last="Brandt">Bernd W. Brandt</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ramage, Gordon" sort="Ramage, Gordon" uniqKey="Ramage G" first="Gordon" last="Ramage">Gordon Ramage</name><affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 378 Sauchiehall Street, Glasgow, G2 3JZ</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title><p>The composition of dental plaque has been well defined, whereas currently there is limited understanding of the composition of denture plaque and how it directly influences denture related stomatitis (DS). The aims of this study were to compare the microbiomes of denture wearers, and to understand the implications of these towards inter-kingdom and host-pathogen interactions within the oral cavity.</p></sec><sec id="sec002"><title>Methods</title><p>Swab samples were obtained from 123 participants wearing either a complete or partial denture; the bacterial composition of each sample was determined using bar-coded illumina MiSeq sequencing of the bacterial hypervariable V4 region of 16S rDNA. Sequencing data processing was undertaken using QIIME, clustered in Operational Taxonomic Units (OTUs) and assigned to taxonomy. The dentures were sonicated to remove the microbial flora residing on the prosthesis, sonicate was then cultured using diagnostic colorex <italic>Candida</italic> media. Samples of unstimulated saliva were obtained and antimicrobial peptides (AMP) levels were measured by ELISA.</p></sec><sec id="sec003"><title>Results</title><p>We have shown that dental and denture plaques are significantly distinct both in composition and diversity and that the oral microbiome composition of a denture wearer is variable and is influenced by the location within the mouth. Dentures and mucosa were predominantly made up of Bacilli and Actinobacteria. Moreover, the presence of natural teeth has a significant impact on the overall microbial composition, when compared to the fully edentulous. Furthermore, increasing levels of <italic>Candida spp</italic>. positively correlate with <italic>Lactobacillus spp</italic>. AMPs were quantified, though showed no specific correlations.</p></sec><sec id="sec004"><title>Conclusions</title><p>This is the first study to provide a detailed understanding of the oral microbiome of denture wearers and has provided evidence that DS development is more complex than simply a candidal infection. 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uniqKey="Erkose G">G Erkose</name></author><author><name sortKey="Kurt, H" uniqKey="Kurt H">H Kurt</name></author><author><name sortKey="Erturan, Z" uniqKey="Erturan Z">Z Erturan</name></author><author><name sortKey="Kutay, O" uniqKey="Kutay O">O Kutay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, Q" uniqKey="Jiang Q">Q Jiang</name></author><author><name sortKey="Stamatova, I" uniqKey="Stamatova I">I Stamatova</name></author><author><name sortKey="Kari, K" uniqKey="Kari K">K Kari</name></author><author><name sortKey="Meurman, Jh" uniqKey="Meurman J">JH Meurman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Visvanathan, V" uniqKey="Visvanathan V">V Visvanathan</name></author><author><name sortKey="Nix, P" uniqKey="Nix P">P Nix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radek, K" uniqKey="Radek K">K Radek</name></author><author><name sortKey="Gallo, R" uniqKey="Gallo R">R Gallo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bals, R" uniqKey="Bals R">R Bals</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Hollande-Septentrionale</li><li>Écosse</li></region><settlement><li>Amsterdam</li><li>Glasgow</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="O Onnell, Lindsay E" sort="O Onnell, Lindsay E" uniqKey="O Onnell L" first="Lindsay E." last="O Onnell">Lindsay E. O Onnell</name></region><name sortKey="Bradshaw, David" sort="Bradshaw, David" uniqKey="Bradshaw D" first="David" last="Bradshaw">David Bradshaw</name><name sortKey="Cross, Laura J" sort="Cross, Laura J" uniqKey="Cross L" first="Laura J." last="Cross">Laura J. Cross</name><name sortKey="Lambert, Margaret" sort="Lambert, Margaret" uniqKey="Lambert M" first="Margaret" last="Lambert">Margaret Lambert</name><name sortKey="Malcolm, Jennifer" sort="Malcolm, Jennifer" uniqKey="Malcolm J" first="Jennifer" last="Malcolm">Jennifer Malcolm</name><name sortKey="Nile, Christopher J" sort="Nile, Christopher J" uniqKey="Nile C" first="Christopher J." last="Nile">Christopher J. Nile</name><name sortKey="Ramage, Gordon" sort="Ramage, Gordon" uniqKey="Ramage G" first="Gordon" last="Ramage">Gordon Ramage</name><name sortKey="Riggio, Marcello" sort="Riggio, Marcello" uniqKey="Riggio M" first="Marcello" last="Riggio">Marcello Riggio</name><name sortKey="Robertson, Douglas" sort="Robertson, Douglas" uniqKey="Robertson D" first="Douglas" last="Robertson">Douglas Robertson</name><name sortKey="Sherriff, Andrea" sort="Sherriff, Andrea" uniqKey="Sherriff A" first="Andrea" last="Sherriff">Andrea Sherriff</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Buijs, Mark J" sort="Buijs, Mark J" uniqKey="Buijs M" first="Mark J." last="Buijs">Mark J. Buijs</name></region><name sortKey="Brandt, Bernd W" sort="Brandt, Bernd W" uniqKey="Brandt B" first="Bernd W." last="Brandt">Bernd W. Brandt</name><name sortKey="Crielaard, Wim" sort="Crielaard, Wim" uniqKey="Crielaard W" first="Wim" last="Crielaard">Wim Crielaard</name><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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